Songqing Fan Selected Research

Eukaryotic Initiation Factor-4E

1/2022	Exosome-mediated miR-7-5p delivery enhances the anticancer effect of Everolimus via blocking MNK/eIF4E axis in non-small cell lung cancer.
1/2020	Overexpression of p-Akt, p-mTOR and p-eIF4E proteins associates with metastasis and unfavorable prognosis in non-small cell lung cancer.
1/2017	Elevated levels of p-Mnk1, p-eIF4E and p-p70S6K proteins are associated with tumor recurrence and poor prognosis in astrocytomas.
1/2017	Suppression Of β-catenin Nuclear Translocation By CGP57380 Decelerates Poor Progression And Potentiates Radiation-Induced Apoptosis in Nasopharyngeal Carcinoma.
5/2016	CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway.
4/2016	4EGI-1 induces apoptosis and enhances radiotherapy sensitivity in nasopharyngeal carcinoma cells via DR5 induction on 4E-BP1 dephosphorylation.
1/2014	Phosphorylated Mnk1 and eIF4E are associated with lymph node metastasis and poor prognosis of nasopharyngeal carcinoma.
3/2012	Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer.
4/2010	The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation.
8/2009	Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues.

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Songqing Fan Research Topics

Disease

71	Neoplasms (Cancer) 05/2022 - 08/2009
33	Nasopharyngeal Carcinoma 01/2022 - 02/2005
27	Neoplasm Metastasis (Metastasis) 06/2022 - 03/2007
20	Carcinogenesis 01/2022 - 07/2005
18	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022 - 03/2012
16	Lymphatic Metastasis 08/2020 - 09/2012
12	Lung Neoplasms (Lung Cancer) 12/2021 - 03/2012
11	Breast Neoplasms (Breast Cancer) 01/2022 - 07/2011
6	Adenocarcinoma of Lung 06/2022 - 01/2019
5	Squamous Cell Carcinoma (Epidermoid Carcinoma) 06/2022 - 01/2021
5	Squamous Cell Carcinoma of Head and Neck 01/2017 - 04/2010
4	Colorectal Neoplasms (Colorectal Cancer) 02/2020 - 06/2009
4	Nasopharyngeal Neoplasms (Cancer of the Nasopharynx) 11/2019 - 09/2012
4	Inflammation (Inflammations) 01/2019 - 01/2014
3	Carcinoma (Carcinomatosis) 03/2022 - 09/2012
2	Pathologic Processes 01/2020 - 03/2019
2	Disease Progression 10/2019 - 06/2019
2	Lung Diseases (Lung Disease) 08/2019 - 01/2019
2	Ductal Carcinoma 01/2018 - 10/2014
2	Hyperplasia 01/2018 - 01/2014
2	Colitis 10/2017 - 01/2014
2	Astrocytoma (Pilocytic Astrocytoma) 01/2017 - 01/2017
2	Infections 01/2017 - 01/2012
2	Glioma (Gliomas) 01/2017 - 07/2011
2	Pancreatic Neoplasms (Pancreatic Cancer) 03/2016 - 04/2010
2	Epstein-Barr Virus Infections 12/2015 - 01/2012
1	Squamous Cell Neoplasms (Squamous Cell Cancer) 10/2020

Drug/Important Bio-Agent (IBA)

41	Proteins (Proteins, Gene)FDA Link 06/2022 - 07/2005
16	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2013
10	Messenger RNA (mRNA)IBA 06/2022 - 06/2012
10	Eukaryotic Initiation Factor-4EIBA 01/2022 - 08/2009
9	Peptide Initiation Factors (Initiation Factor)IBA 01/2022 - 08/2009
9	Cyclin D1IBA 08/2020 - 05/2009
7	MicroRNAs (MicroRNA)IBA 01/2020 - 07/2011
6	Phosphotransferases (Kinase)IBA 01/2022 - 01/2013
5	B7-H1 AntigenIBA 02/2022 - 10/2020
5	osimertinibIBA 10/2021 - 01/2020
4	ErbB Receptors (EGF Receptor)IBA 10/2021 - 01/2019
4	CateninsIBA 01/2021 - 07/2013
4	RNA (Ribonucleic Acid)IBA 01/2021 - 03/2007
4	Complementary DNA (cDNA)IBA 11/2014 - 02/2007
3	Small Interfering RNA (siRNA)IBA 06/2022 - 04/2010
3	Long Noncoding RNAIBA 01/2022 - 02/2020
3	Biological ProductsIBA 01/2022 - 03/2019
3	Everolimus FDA Link 01/2022 - 05/2016
3	TOR Serine-Threonine KinasesIBA 01/2021 - 05/2016
3	ParaffinIBA 01/2021 - 01/2017
3	Untranslated RNA (Noncoding RNA)IBA 02/2020 - 10/2013
3	CGP 57380IBA 10/2019 - 05/2016
3	Paclitaxel (Taxol)FDA LinkGeneric 03/2019 - 01/2015
3	Chaperonin 10IBA 01/2017 - 01/2017
3	LactoferrinIBA 02/2015 - 01/2012
3	flotillinsIBA 01/2015 - 01/2014
2	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 01/2021 - 08/2010
2	Matrix Metalloproteinases (MMPs)IBA 01/2021 - 01/2017
2	LigandsIBA 01/2021 - 01/2019
2	Programmed Cell Death 1 ReceptorIBA 01/2021 - 01/2020
2	Indicators and Reagents (Reagents)IBA 08/2020 - 01/2020
2	Histone Deacetylase InhibitorsIBA 01/2020 - 04/2010
2	PanobinostatIBA 01/2020 - 04/2010
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 11/2019 - 11/2014
2	Carrier Proteins (Binding Protein)IBA 10/2019 - 04/2010
2	LipidsIBA 09/2018 - 01/2015
2	Insulin Receptor Substrate ProteinsIBA 01/2018 - 01/2014
2	Progesterone Receptors (Progesterone Receptor)IBA 01/2017 - 03/2012
2	VimentinIBA 01/2017 - 06/2014
2	Estrogens (Estrogen)FDA Link 01/2017 - 03/2012
2	Eukaryotic Initiation Factor-4G (Eukaryotic Initiation Factor 4G)IBA 04/2016 - 04/2010
2	Phenobarbital (Luminal)FDA Link 01/2015 - 03/2012
2	Epidermal Growth Factor (EGF)IBA 01/2015 - 02/2005
2	Epstein-Barr virus encoded RNA 1IBA 10/2013 - 05/2009
2	Caspase 8 (Caspase-8)IBA 04/2013 - 08/2010
1	jujuboside AIBA 06/2022
1	Ribosomal Protein S6IBA 05/2022
1	LycopeneIBA 02/2022
1	DNA (Deoxyribonucleic Acid)IBA 01/2022
1	CationsIBA 01/2022
1	UbiquitinIBA 01/2022
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2022
1	Mitogen-Activated Protein KinasesIBA 01/2022
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2022
1	Transient Receptor Potential ChannelsIBA 01/2022
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 06/2021
1	N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamideIBA 06/2021
1	Cisplatin (Platino)FDA LinkGeneric 01/2021
1	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2021
1	Antisense RNA (Anti-Sense RNA)IBA 01/2021
1	Metalloproteases (Metalloproteinases)IBA 01/2021
1	Tyrosine Kinase InhibitorsIBA 01/2021
1	Transcription Factors (Transcription Factor)IBA 01/2021
1	Peptides (Polypeptides)IBA 10/2020
1	Myeloid Cell Leukemia Sequence 1 ProteinIBA 10/2020
1	MucinsIBA 08/2020
1	tyrosine receptor (receptor, tyrosine)IBA 08/2020
1	fascinIBA 02/2020

Therapy/Procedure

19	Therapeutics 02/2022 - 04/2007
7	Radiotherapy 03/2022 - 01/2014
7	Drug Therapy (Chemotherapy) 01/2020 - 01/2014
4	Immunotherapy 12/2021 - 12/2019
1	Aftercare (After-Treatment) 01/2022